Dznep, a histone modification inhibitor, inhibits HIF1α binding to TIMP2 gene and suppresses TIMP2 expression under hypoxia

Epidemiological studies have shown that patients who recovered from acute kidney injury (AKI) may subsequently develop chronic kidney disease (CKD). AKI is primarily caused by renal hypoxia, and it causes epigenetic alterations, known as hypoxic memory. 3‐Deazaneplanocin A (Dznep), an inhibitor of h...

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Detalles Bibliográficos
Autores principales: Yamazaki, Tomotaka, Mimura, Imari, Kurata, Yu, Tanaka, Tetsuhiro, Nangaku, Masaomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502026/
https://www.ncbi.nlm.nih.gov/pubmed/37710084
http://dx.doi.org/10.14814/phy2.15810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502026/
https://www.ncbi.nlm.nih.gov/pubmed/37710084
http://dx.doi.org/10.14814/phy2.15810

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