Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells

HELLS/LSH (Helicase, Lymphoid Specific) is a SNF2-like chromatin remodelling protein involved in DNA methylation. Its loss-of-function in humans causes humoral immunodeficiency, called ICF4 syndrome (Immunodeficiency, Centromeric Instability, Facial anomalies). Here we show by our newly generated B-...

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Detalles Bibliográficos
Autores principales: Cousu, Clara, Mulot, Eléonore, De Smet, Annie, Formichetti, Sara, Lecoeuche, Damiana, Ren, Jianke, Muegge, Kathrin, Boulard, Matthieu, Weill, Jean-Claude, Reynaud, Claude-Agnès, Storck, Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502085/
https://www.ncbi.nlm.nih.gov/pubmed/37709749
http://dx.doi.org/10.1038/s41467-023-41317-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502085/
https://www.ncbi.nlm.nih.gov/pubmed/37709749
http://dx.doi.org/10.1038/s41467-023-41317-3

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