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Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells
HELLS/LSH (Helicase, Lymphoid Specific) is a SNF2-like chromatin remodelling protein involved in DNA methylation. Its loss-of-function in humans causes humoral immunodeficiency, called ICF4 syndrome (Immunodeficiency, Centromeric Instability, Facial anomalies). Here we show by our newly generated B-...
Autores principales: | Cousu, Clara, Mulot, Eléonore, De Smet, Annie, Formichetti, Sara, Lecoeuche, Damiana, Ren, Jianke, Muegge, Kathrin, Boulard, Matthieu, Weill, Jean-Claude, Reynaud, Claude-Agnès, Storck, Sébastien |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502085/ https://www.ncbi.nlm.nih.gov/pubmed/37709749 http://dx.doi.org/10.1038/s41467-023-41317-3 |
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