A biocatalytic platform for asymmetric alkylation of α-keto acids by mining and engineering of methyltransferases

Catalytic asymmetric α-alkylation of carbonyl compounds represents a long-standing challenge in synthetic organic chemistry. Herein, we advance a dual biocatalytic platform for the efficient asymmetric alkylation of α-keto acids. First, guided by our recently obtained crystal structures, we develop...

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Detalles Bibliográficos
Autores principales: Ju, Shuyun, Kuzelka, Kaylee P., Guo, Rui, Krohn-Hansen, Benjamin, Wu, Jianping, Nair, Satish K., Yang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502145/
https://www.ncbi.nlm.nih.gov/pubmed/37709735
http://dx.doi.org/10.1038/s41467-023-40980-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502145/
https://www.ncbi.nlm.nih.gov/pubmed/37709735
http://dx.doi.org/10.1038/s41467-023-40980-w

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