Molecular profiling and specific targeting of gemcitabine-resistant subclones in heterogeneous pancreatic cancer cell populations

PURPOSE: Chemotherapy is pivotal in the multimodal treatment of pancreatic ductal adenocarcinoma (PDAC). Technical advances unveiled a high degree of inter- and intratumoral heterogeneity. We hypothesized that intratumoral heterogeneity (ITH) impacts response to gemcitabine treatment and demands spe...

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Detalles Bibliográficos
Autores principales: Färber, Benedikt, Lapshyna, Olga, Künstner, Axel, Kohl, Michael, Sauer, Thorben, Bichmann, Kira, Heckelmann, Benjamin, Watzelt, Jessica, Honselmann, Kim, Bolm, Louisa, ten Winkel, Meike, Busch, Hauke, Ungefroren, Hendrik, Keck, Tobias, Gemoll, Timo, Wellner, Ulrich F., Braun, Rüdiger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502231/
https://www.ncbi.nlm.nih.gov/pubmed/37719017
http://dx.doi.org/10.3389/fonc.2023.1230382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502231/
https://www.ncbi.nlm.nih.gov/pubmed/37719017
http://dx.doi.org/10.3389/fonc.2023.1230382

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