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The synthetic food dye, Red 40, causes DNA damage, causes colonic inflammation, and impacts the microbiome in mice

The incidence of colorectal cancer (CRC) among young people has been on the rise for the past four decades and its underlying causes are only just starting to be uncovered. Recent studies suggest that consuming ultra-processed foods and pro-inflammatory diets may be contributing factors. The increas...

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Autores principales: Zhang, Qi, Chumanevich, Alexander A., Nguyen, Ivy, Chumanevich, Anastasiya A., Sartawi, Nora, Hogan, Jake, Khazan, Minou, Harris, Quinn, Massey, Bryson, Chatzistamou, Ioulia, Buckhaults, Phillip J., Banister, Carolyn E., Wirth, Michael, Hebert, James R., Murphy, E. Angela, Hofseth, Lorne J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502305/
https://www.ncbi.nlm.nih.gov/pubmed/37719200
http://dx.doi.org/10.1016/j.toxrep.2023.08.006
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author Zhang, Qi
Chumanevich, Alexander A.
Nguyen, Ivy
Chumanevich, Anastasiya A.
Sartawi, Nora
Hogan, Jake
Khazan, Minou
Harris, Quinn
Massey, Bryson
Chatzistamou, Ioulia
Buckhaults, Phillip J.
Banister, Carolyn E.
Wirth, Michael
Hebert, James R.
Murphy, E. Angela
Hofseth, Lorne J.
author_facet Zhang, Qi
Chumanevich, Alexander A.
Nguyen, Ivy
Chumanevich, Anastasiya A.
Sartawi, Nora
Hogan, Jake
Khazan, Minou
Harris, Quinn
Massey, Bryson
Chatzistamou, Ioulia
Buckhaults, Phillip J.
Banister, Carolyn E.
Wirth, Michael
Hebert, James R.
Murphy, E. Angela
Hofseth, Lorne J.
author_sort Zhang, Qi
collection PubMed
description The incidence of colorectal cancer (CRC) among young people has been on the rise for the past four decades and its underlying causes are only just starting to be uncovered. Recent studies suggest that consuming ultra-processed foods and pro-inflammatory diets may be contributing factors. The increase in the use of synthetic food colors in such foods over the past 40 years, including the common synthetic food dye Allura Red AC (Red 40), coincides with the rise of early-onset colorectal cancer (EOCRC). As these ultra-processed foods are particularly appealing to children, there is a growing concern about the impact of synthetic food dyes on the development of CRC. Our study aimed to investigate the effects of Red 40 on DNA damage, the microbiome, and colonic inflammation. Despite a lack of prior research, high levels of human exposure to pro-inflammatory foods containing Red 40 highlight the urgency of exploring this issue. Our results show that Red 40 damages DNA both in vitro and in vivo and that consumption of Red 40 in the presence of a high-fat diet for 10 months leads to dysbiosis and low-grade colonic inflammation in mice. This evidence supports the hypothesis that Red 40 is a dangerous compound that dysregulates key players involved in the development of EOCRC.
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spelling pubmed-105023052023-09-16 The synthetic food dye, Red 40, causes DNA damage, causes colonic inflammation, and impacts the microbiome in mice Zhang, Qi Chumanevich, Alexander A. Nguyen, Ivy Chumanevich, Anastasiya A. Sartawi, Nora Hogan, Jake Khazan, Minou Harris, Quinn Massey, Bryson Chatzistamou, Ioulia Buckhaults, Phillip J. Banister, Carolyn E. Wirth, Michael Hebert, James R. Murphy, E. Angela Hofseth, Lorne J. Toxicol Rep Article The incidence of colorectal cancer (CRC) among young people has been on the rise for the past four decades and its underlying causes are only just starting to be uncovered. Recent studies suggest that consuming ultra-processed foods and pro-inflammatory diets may be contributing factors. The increase in the use of synthetic food colors in such foods over the past 40 years, including the common synthetic food dye Allura Red AC (Red 40), coincides with the rise of early-onset colorectal cancer (EOCRC). As these ultra-processed foods are particularly appealing to children, there is a growing concern about the impact of synthetic food dyes on the development of CRC. Our study aimed to investigate the effects of Red 40 on DNA damage, the microbiome, and colonic inflammation. Despite a lack of prior research, high levels of human exposure to pro-inflammatory foods containing Red 40 highlight the urgency of exploring this issue. Our results show that Red 40 damages DNA both in vitro and in vivo and that consumption of Red 40 in the presence of a high-fat diet for 10 months leads to dysbiosis and low-grade colonic inflammation in mice. This evidence supports the hypothesis that Red 40 is a dangerous compound that dysregulates key players involved in the development of EOCRC. Elsevier 2023-09-06 /pmc/articles/PMC10502305/ /pubmed/37719200 http://dx.doi.org/10.1016/j.toxrep.2023.08.006 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Zhang, Qi
Chumanevich, Alexander A.
Nguyen, Ivy
Chumanevich, Anastasiya A.
Sartawi, Nora
Hogan, Jake
Khazan, Minou
Harris, Quinn
Massey, Bryson
Chatzistamou, Ioulia
Buckhaults, Phillip J.
Banister, Carolyn E.
Wirth, Michael
Hebert, James R.
Murphy, E. Angela
Hofseth, Lorne J.
The synthetic food dye, Red 40, causes DNA damage, causes colonic inflammation, and impacts the microbiome in mice
title The synthetic food dye, Red 40, causes DNA damage, causes colonic inflammation, and impacts the microbiome in mice
title_full The synthetic food dye, Red 40, causes DNA damage, causes colonic inflammation, and impacts the microbiome in mice
title_fullStr The synthetic food dye, Red 40, causes DNA damage, causes colonic inflammation, and impacts the microbiome in mice
title_full_unstemmed The synthetic food dye, Red 40, causes DNA damage, causes colonic inflammation, and impacts the microbiome in mice
title_short The synthetic food dye, Red 40, causes DNA damage, causes colonic inflammation, and impacts the microbiome in mice
title_sort synthetic food dye, red 40, causes dna damage, causes colonic inflammation, and impacts the microbiome in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502305/
https://www.ncbi.nlm.nih.gov/pubmed/37719200
http://dx.doi.org/10.1016/j.toxrep.2023.08.006
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