Increased copy number of the target gene squalene monooxygenase as the main resistance mechanism to terbinafine in Leishmania infantum()

We use here two genomic screens in an attempt to understand the mode of action and resistance mechanism of terbinafine, an antifungal contemplated as a potential drug against the parasite Leishmania. One screen consisted in in vitro drug evolution where 5 independent mutants were selected step-by-st...

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Detalles Bibliográficos
Autores principales: Potvin, Jade-Éva, Fani, Fereshteh, Queffeulou, Marine, Gazanion, Élodie, Leprohon, Philippe, Ouellette, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Regular article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502319/
https://www.ncbi.nlm.nih.gov/pubmed/37703646
http://dx.doi.org/10.1016/j.ijpddr.2023.09.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502319/
https://www.ncbi.nlm.nih.gov/pubmed/37703646
http://dx.doi.org/10.1016/j.ijpddr.2023.09.001

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