ER-trafficking triggers NRF1 ubiquitination to promote its proteolytic activation

The transcription factor NRF1 resides in the endoplasmic reticulum (ER) and is constantly transported to the cytosol for proteasomal degradation. However, when the proteasome is defective, NRF1 escapes degradation and undergoes proteolytic cleavage by the protease DDI2, generating a transcriptionall...

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Detalles Bibliográficos
Autores principales: Chavarria, Claire, Zaffalon, Léa, Ribeiro, Sérgio T., Op, Mélanie, Quadroni, Manfredo, Iatrou, Maria Sofia, Chapuis, Chloé, Martinon, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502413/
https://www.ncbi.nlm.nih.gov/pubmed/37720101
http://dx.doi.org/10.1016/j.isci.2023.107777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502413/
https://www.ncbi.nlm.nih.gov/pubmed/37720101
http://dx.doi.org/10.1016/j.isci.2023.107777

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