CD25(high) Effector Regulatory T Cells Hamper Responses to PD-1 Blockade in Triple-Negative Breast Cancer

Regulatory T cells (Treg) impede effective antitumor immunity. However, the role of Tregs in the clinical outcomes of patients with triple-negative breast cancer (TNBC) remains controversial. Here, we found that an immunosuppressive TNBC microenvironment is marked by an imbalance between effector αβ...

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Detalles Bibliográficos
Autores principales: Fattori, Stéphane, Le Roy, Aude, Houacine, Jemila, Robert, Lucie, Abes, Riad, Gorvel, Laurent, Granjeaud, Samuel, Rouvière, Marie-Sarah, Ben Amara, Amira, Boucherit, Nicolas, Tarpin, Carole, Pakradouni, Jihane, Charafe-Jauffret, Emmanuelle, Houvenaeghel, Gilles, Lambaudie, Eric, Bertucci, François, Rochigneux, Philippe, Gonçalves, Anthony, Foussat, Arnaud, Chrétien, Anne-Sophie, Olive, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Cancer Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502453/
https://www.ncbi.nlm.nih.gov/pubmed/37379438
http://dx.doi.org/10.1158/0008-5472.CAN-23-0613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502453/
https://www.ncbi.nlm.nih.gov/pubmed/37379438
http://dx.doi.org/10.1158/0008-5472.CAN-23-0613

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