Cargando…

Mutant KRAS Mediates circARFGEF2 Biogenesis to Promote Lymphatic Metastasis of Pancreatic Ductal Adenocarcinoma

Circular RNAs (circRNA) contribute to cancer stemness, proliferation, and metastasis. The biogenesis of circRNAs can be impacted by the genetic landscape of tumors. Herein, we identified a novel circRNA, circARFGEF2 (hsa_circ_0060665), which was upregulated in KRAS(G12D) pancreatic ductal adenocarci...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kong, Yao, Luo, Yuming, Zheng, Shangyou, Yang, Jiabin, Zhang, Dingwen, Zhao, Yue, Zheng, Hanhao, An, Mingjie, Lin, Yan, Ai, Le, Diao, Xiayao, Lin, Qing, Chen, Changhao, Chen, Rufu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Cancer Metabolism and Molecular Mechanisms
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502454/ https://www.ncbi.nlm.nih.gov/pubmed/37363990 http://dx.doi.org/10.1158/0008-5472.CAN-22-3997

Ejemplares similares

Extracellular vesicle-mediated heterogeneous communication between cancer and the lymphatic system facilitates lymphatic metastasis
por: Chen, Changhao, et al.
Publicado: (2023)

KRAS mutant–driven SUMOylation controls extracellular vesicle transmission to trigger lymphangiogenesis in pancreatic cancer
por: Luo, Yuming, et al.
Publicado: (2022)

Aberrant Nuclear Export of circNCOR1 Underlies SMAD7-Mediated Lymph Node Metastasis of Bladder Cancer
por: An, Mingjie, et al.
Publicado: (2022)

An HGF‐dependent positive feedback loop between bladder cancer cells and fibroblasts mediates lymphangiogenesis and lymphatic metastasis
por: Li, Yuting, et al.
Publicado: (2023)

circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer
por: Kong, Yao, et al.
Publicado: (2020)

SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer
por: Diao, Xiayao, et al.
Publicado: (2023)

ZEB1-mediated biogenesis of circNIPBL sustains the metastasis of bladder cancer via Wnt/β-catenin pathway
por: Li, Yuanlong, et al.
Publicado: (2023)

Single-cell RNA sequencing reveals spatiotemporal heterogeneity and malignant progression in pancreatic neuroendocrine tumor
por: Zhou, Yu, et al.
Publicado: (2021)

Tumor‐derived exosomal BCYRN1 activates WNT5A/VEGF‐C/VEGFR3 feedforward loop to drive lymphatic metastasis of bladder cancer
por: Zheng, Hanhao, et al.
Publicado: (2021)

Regulation of a Golgi Flippase by Phosphoinositides and an ArfGEF
por: Natarajan, Paramasivam, et al.
Publicado: (2009)

Characterization of heterogeneous metabolism in hepatocellular carcinoma identifies new therapeutic target and treatment strategy
por: Yang, Jiabin, et al.
Publicado: (2023)

HIF‐2α regulates non‐canonical glutamine metabolism via activation of PI3K/mTORC2 pathway in human pancreatic ductal adenocarcinoma
por: Li, Wenzhu, et al.
Publicado: (2017)

Linc00511 acts as a competing endogenous RNA to regulate VEGFA expression through sponging hsa‐miR‐29b‐3p in pancreatic ductal adenocarcinoma
por: Zhao, Xiaohui, et al.
Publicado: (2017)

Lymphatic metastasis in non‐small cell lung cancer: recent discoveries and novel therapeutic targets
por: Diao, Xiayao, et al.
Publicado: (2022)

lncRNA-PLACT1 sustains activation of NF-κB pathway through a positive feedback loop with IκBα/E2F1 axis in pancreatic cancer
por: Ren, Xiaofan, et al.
Publicado: (2020)

Correction: lncRNA-PLACT1 sustains activation of NF-κB pathway through a positive feedback loop with IκBα/E2F1 axis in pancreatic cancer
por: Ren, Xiaofan, et al.
Publicado: (2022)

Movement disorder and neuronal migration disorder due to ARFGEF2 mutation
por: de Wit, M. C. Y., et al.
Publicado: (2009)

Expanding the Phenotypic and Genotypic Spectrum of ARFGEF1-Related Neurodevelopmental Disorder
por: Xu, Lu, et al.
Publicado: (2022)

circCUL2 induces an inflammatory CAF phenotype in pancreatic ductal adenocarcinoma via the activation of the MyD88-dependent NF-κB signaling pathway
por: Zheng, Shangyou, et al.
Publicado: (2022)

Tumor-associated macrophages promote progression and the Warburg effect via CCL18/NF-kB/VCAM-1 pathway in pancreatic ductal adenocarcinoma
por: Ye, Huilin, et al.
Publicado: (2018)

Integrated Conformational and Lipid-Sensing Regulation of Endosomal ArfGEF BRAG2
por: Aizel, Kaheina, et al.
Publicado: (2013)

circEHBP1 promotes lymphangiogenesis and lymphatic metastasis of bladder cancer via miR-130a-3p/TGFβR1/VEGF-D signaling
por: Zhu, Jiang, et al.
Publicado: (2021)

A novel gene signature for prognosis prediction and chemotherapy response in patients with pancreatic cancer
por: Lin, Hongcao, et al.
Publicado: (2021)

High expression of AFAP1-AS1 is associated with poor survival and short-term recurrence in pancreatic ductal adenocarcinoma
por: Ye, Yibiao, et al.
Publicado: (2015)

FEZF1-AS1/miR-107/ZNF312B axis facilitates progression and Warburg effect in pancreatic ductal adenocarcinoma
por: Ye, Huilin, et al.
Publicado: (2018)

A Novel Membrane Sensor Controls the Localization and ArfGEF Activity of Bacterial RalF
por: Folly-Klan, Marcia, et al.
Publicado: (2013)

The ArfGEF GBF-1 Is Required for ER Structure, Secretion and Endocytic Transport in C. elegans
por: Ackema, Karin B., et al.
Publicado: (2013)

BIG1/Arfgef1 and Arf1 regulate the initiation of myelination by Schwann cells in mice
por: Miyamoto, Yuki, et al.
Publicado: (2018)

BRD9 Degradation Disrupts Ribosome Biogenesis in Multiple Myeloma
por: Kurata, Keiji, et al.
Publicado: (2023)

Poliovirus replication requires the N‐terminus but not the catalytic Sec7 domain of ArfGEF GBF1
por: Belov, George A., et al.
Publicado: (2010)

MicroRNA‐27b suppresses tumor progression by regulating ARFGEF1 and focal adhesion signaling
por: Matsuyama, Rei, et al.
Publicado: (2015)

Different Vancomycin-Intermediate Staphylococcus aureus Phenotypes Selected from the Same ST100-hVISA Parental Strain
por: Di Gregorio, Sabrina, et al.
Publicado: (2017)

Pilot Screening to Determine Antimicrobial Synergies in a Multidrug-Resistant Bacterial Strain Library
por: Kim, Si-Hyun, et al.
Publicado: (2016)

Genomic Characterization of Nonclonal mcr-1-Positive Multidrug-Resistant Klebsiella pneumoniae from Clinical Samples in Thailand
por: Srijan, Apichai, et al.
Publicado: (2018)

Morphological and Biological Characteristics of Staphylococcus aureus Biofilm Formed in the Presence of Plasma
por: Sato, Ayami, et al.
Publicado: (2019)

Activity of Cefiderocol Against Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii Endemic to Medical Centers in New York City
por: Iregui, Alejandro, et al.
Publicado: (2020)

Resistome and a Novel bla(NDM-1)-Harboring Plasmid of an Acinetobacter haemolyticus Strain from a Children's Hospital in Puebla, Mexico
por: Bello-López, Elena, et al.
Publicado: (2019)

Alliance of Efflux Pumps with β-Lactamases in Multidrug-Resistant Klebsiella pneumoniae Isolates
por: Maurya, Navdezda, et al.
Publicado: (2019)

Mechanisms of Reduced Susceptibility to Cefiderocol Among Isolates from the CREDIBLE-CR and APEKS-NP Clinical Trials
por: Nordmann, Patrice, et al.
Publicado: (2022)

Antimicrobial Resistance and Molecular Characterization of Gene Cassettes from Class 1 Integrons in Escherichia coli Strains
por: Li, Wanxiang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hb7sjip5reag7i3jefpcto2l9l