Transcriptomic Signatures of MSI-High Metastatic Colorectal Cancer Predict Efficacy of Immune Checkpoint Inhibitors

PURPOSE: Microsatellite instability (MSI) is currently the only predictive biomarker of efficacy of immune checkpoint inhibitors (ICI) in metastatic colorectal cancers (mCRC). However, 10% to 40% of patients with MSI mCRC will experience a primary resistance to ICI. EXPERIMENTAL DESIGN: In two cohor...

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Detalles Bibliográficos
Autores principales: Gallois, Claire, Landi, Matteo, Taieb, Julien, Sroussi, Marine, Saberzadeh-Ardestani, Bahar, Cazelles, Antoine, Lonardi, Sara, Bergamo, Francesca, Intini, Rossana, Maddalena, Giulia, Pietrantonio, Filippo, Corti, Francesca, Ambrosini, Margherita, Martinetti, Antonia, Germani, Marco Maria, Boccaccio, Chiara, Vetere, Guglielmo, Mouillet-Richard, Sophie, de Reynies, Aurélien, Sinicrope, Frank A., Cremolini, Chiara, Laurent-Puig, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502457/
https://www.ncbi.nlm.nih.gov/pubmed/37439810
http://dx.doi.org/10.1158/1078-0432.CCR-22-3964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502457/
https://www.ncbi.nlm.nih.gov/pubmed/37439810
http://dx.doi.org/10.1158/1078-0432.CCR-22-3964

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