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Esophageal cancer stem cells reduce hypoxia-induced apoptosis by inhibiting the GRP78-perk-eIF2α-ATF4-CHOP pathway in vitro

BACKGROUND: Due to the abnormal angiogenesis, cancer stem cells (CSCs) in esophageal cancer (EC) have the characteristics of a hypoxic microenvironment. However, they can resist hypoxia-induced apoptosis. the molecular mechanism underlying the resistance of esophageal CSCs to hypoxia-induced apoptos...

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Detalles Bibliográficos
Autores principales: Lin, Ruijiang, Ma, Minjie, Han, Biao, Zheng, Ya, Wang, Yuping, Zhou, Yongning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502543/
https://www.ncbi.nlm.nih.gov/pubmed/37720449
http://dx.doi.org/10.21037/jgo-23-462