AKT inhibition generates potent polyfunctional clinical grade AUTO1 CAR T-cells, enhancing function and survival

BACKGROUND: AUTO1 is a fast off-rate CD19-targeting chimeric antigen receptor (CAR), which has been successfully tested in adult lymphoblastic leukemia. Tscm/Tcm-enriched CAR-T populations confer the best expansion and persistence, but Tscm/Tcm numbers are poor in heavily pretreated adult patients....

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Detalles Bibliográficos
Autores principales: Mehra, Vedika, Agliardi, Giulia, Dias Alves Pinto, Juliana, Shafat, Manar S, Garai, Amaia Cadinanos, Green, Louisa, Hotblack, Alastair, Arce Vargas, Fred, Peggs, Karl S, van der Waart, Anniek B, Dolstra, Harry, Pule, Martin A, Roddie, Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503365/
https://www.ncbi.nlm.nih.gov/pubmed/37709295
http://dx.doi.org/10.1136/jitc-2023-007002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503365/
https://www.ncbi.nlm.nih.gov/pubmed/37709295
http://dx.doi.org/10.1136/jitc-2023-007002

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