Hexamethylene amiloride binds the SARS‐CoV‐2 envelope protein at the protein–lipid interface

The SARS‐CoV‐2 envelope (E) protein forms a five‐helix bundle in lipid bilayers whose cation‐conducting activity is associated with the inflammatory response and respiratory distress symptoms of COVID‐19. E channel activity is inhibited by the drug 5‐(N,N‐hexamethylene) amiloride (HMA). However, the...

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Detalles Bibliográficos
Autores principales: Somberg, Noah H., Medeiros‐Silva, João, Jo, Hyunil, Wang, Jun, DeGrado, William F., Hong, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503410/
https://www.ncbi.nlm.nih.gov/pubmed/37632140
http://dx.doi.org/10.1002/pro.4755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503410/
https://www.ncbi.nlm.nih.gov/pubmed/37632140
http://dx.doi.org/10.1002/pro.4755

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