Cargando…

Hexamethylene amiloride binds the SARS‐CoV‐2 envelope protein at the protein–lipid interface

The SARS‐CoV‐2 envelope (E) protein forms a five‐helix bundle in lipid bilayers whose cation‐conducting activity is associated with the inflammatory response and respiratory distress symptoms of COVID‐19. E channel activity is inhibited by the drug 5‐(N,N‐hexamethylene) amiloride (HMA). However, the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Somberg, Noah H., Medeiros‐Silva, João, Jo, Hyunil, Wang, Jun, DeGrado, William F., Hong, Mei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503410/ https://www.ncbi.nlm.nih.gov/pubmed/37632140 http://dx.doi.org/10.1002/pro.4755

Ejemplares similares

Antifungal activity of 6-substituted amiloride and hexamethylene amiloride (HMA) analogs
por: Vu, Kiem, et al.
Publicado: (2023)

Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication
por: Wilson, Lauren, et al.
Publicado: (2006)

In Silico Evaluation of Hexamethylene Amiloride Derivatives as Potential Luminal Inhibitors of SARS-CoV-2 E Protein
por: Jalily, Pouria H., et al.
Publicado: (2022)

Interactions of SARS-CoV-2 envelope protein with amilorides correlate with antiviral activity
por: Park, Sang Ho, et al.
Publicado: (2021)

6-Furopyridine Hexamethylene Amiloride Is a Non-Selective P2X7 Receptor Antagonist
por: Cuthbertson, Peter, et al.
Publicado: (2022)

Inhibition of the regulation of intracellular pH: potential of 5-(N,N-hexamethylene) amiloride in tumour-selective therapy.
por: Luo, J., et al.
Publicado: (1994)

Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride
por: Zhao, Linlin, et al.
Publicado: (2016)

Fluorescence properties of the Na(+)/H(+) exchanger inhibitor HMA (5-(N,N-hexamethylene) amiloride) are modulated by intracellular Ph
por: Giansanti, V., et al.
Publicado: (2012)

The Cationic Amphiphilic Drug Hexamethylene Amiloride Eradicates Bulk Breast Cancer Cells and Therapy-Resistant Subpopulations with Similar Efficiencies
por: Berg, Anastasia L., et al.
Publicado: (2022)

Brilacidin, a COVID‐19 drug candidate, demonstrates broad‐spectrum antiviral activity against human coronaviruses OC43, 229E, and NL63 through targeting both the virus and the host cell
por: Hu, Yanmei, et al.
Publicado: (2022)

Structure of the Amantadine Binding Site of Influenza M2 Proton Channels In Lipid Bilayers
por: Cady, Sarah D., et al.
Publicado: (2010)

Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers
por: Mandala, Venkata S., et al.
Publicado: (2020)

Atomic structure of the open SARS-CoV-2 E viroporin
por: Medeiros-Silva, João, et al.
Publicado: (2023)

Synthesis and Evaluation of Poly(hexamethylene-urethane) and PEG-Poly(hexamethylene-urethane) and Their Cholesteryl Oleyl Carbonate Composites for Human Blood Biocompatibility
por: Shih, Mei Fen, et al.
Publicado: (2011)

The Cytoplasmic Domain of the SARS-CoV-2 Envelope Protein Assembles into a β-Sheet Bundle in Lipid Bilayers
por: Dregni, Aurelio J., et al.
Publicado: (2023)

Stapled Voltage-Gated Calcium Channel (Ca(V)) α-Interaction Domain (AID) Peptides Act As Selective Protein–Protein Interaction Inhibitors of Ca(V) Function
por: Findeisen, Felix, et al.
Publicado: (2017)

A Real-Time All-Atom Structural Search Engine for Proteins
por: Gonzalez, Gabriel, et al.
Publicado: (2014)

Development of immunoassays for biomonitoring of hexamethylene diisocyanate exposure.
por: Lemus, R, et al.
Publicado: (2001)

Hexamethylene Tetramine in Septic Inflammations of the Cornea and Conjunctiva
por: Kirkpatrick, H.
Publicado: (1915)

Amiloride: A review
por: Sun, Qianhui, et al.
Publicado: (2020)

Altering the O(2)-Dependent Reactivity of de novo Due Ferri Proteins
por: Reig, Amanda J., et al.
Publicado: (2012)

4-Cyanoindole-2′-deoxyribonucleoside as a Dual Fluorescence and Infrared Probe of DNA Structure and Dynamics
por: Ahmed, Ismail A., et al.
Publicado: (2019)

Structure and Drug Binding of the SARS-CoV-2 Envelope Protein in Phospholipid Bilayers
por: Mandala, Venkata S., et al.
Publicado: (2020)

Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel
por: Wu, Yibing, et al.
Publicado: (2014)

Influence of Genetic Variance on Biomarker Levels After Occupational Exposure to 1,6-Hexamethylene Diisocyanate Monomer and 1,6-Hexamethylene Diisocyanate Isocyanurate
por: Taylor, Laura W., et al.
Publicado: (2020)

Structural organization and interactions of transmembrane domains in tetraspanin proteins
por: Kovalenko, Oleg V, et al.
Publicado: (2005)

Functional Analysis of the Transmembrane Domain in Paramyxovirus F Protein-Mediated Membrane Fusion
por: Bissonnette, Mei Lin Z., et al.
Publicado: (2009)

SNAC-tag for Sequence-specific Chemical Protein Cleavage
por: Dang, Bobo, et al.
Publicado: (2019)

Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics
por: Watkins, Laura C., et al.
Publicado: (2020)

Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures
por: Martina, Zafferani, et al.
Publicado: (2020)

Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures
por: Zafferani, Martina, et al.
Publicado: (2021)

Amiloride hydrochloride methanol disolvate
por: Ton, Cuong Quoc, et al.
Publicado: (2010)

Pharmacokinetics of intranasal amiloride in healthy volunteers
por: Yellepeddi, Venkata K., et al.
Publicado: (2023)

De novo design of a homo-trimeric amantadine-binding protein
por: Park, Jooyoung, et al.
Publicado: (2019)

Lipid and protein dynamics that shape nuclear envelope identity
por: Bahmanyar, Shirin, et al.
Publicado: (2020)

Coronavirus Envelope Protein: Lipid Sensitivity and Membrane Bending
por: Sandberg, Jesse, et al.
Publicado: (2021)

Enhancement of the radiosensitivity of two human tumour cell lines by hexamethylene bisacetamide.
por: Bill, C. A., et al.
Publicado: (1990)

Study of Epigenetic Properties of Poly(HexaMethylene Biguanide) Hydrochloride (PHMB)
por: Creppy, Edmond E., et al.
Publicado: (2014)

Characterization of PLA/PBSeT Blends Prepared with Various Hexamethylene Diisocyanate Contents
por: Kim, Sun Jong, et al.
Publicado: (2021)

Antiseptic Chitosan-Poly(hexamethylene) Biguanide Hydrogel for the Treatment of Infectious Wounds
por: Antony, Irine Rose, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_opn3mgju8ulnd1d20kripg80ot