Multimeric structure of a subfamily III haloalkane dehalogenase‐like enzyme solved by combination of cryo‐EM and x‐ray crystallography

Haloalkane dehalogenase (HLD) enzymes employ an S(N)2 nucleophilic substitution mechanism to erase halogen substituents in diverse organohalogen compounds. Subfamily I and II HLDs are well‐characterized enzymes, but the mode and purpose of multimerization of subfamily III HLDs are unknown. Here we p...

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Detalles Bibliográficos
Autores principales: Chmelova, Klaudia, Gao, Tadeja, Polak, Martin, Schenkmayerova, Andrea, Croll, Tristan I., Shaikh, Tanvir R., Skarupova, Jana, Chaloupkova, Radka, Diederichs, Kay, Read, Randy J., Damborsky, Jiri, Novacek, Jiri, Marek, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503415/
https://www.ncbi.nlm.nih.gov/pubmed/37574754
http://dx.doi.org/10.1002/pro.4751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503415/
https://www.ncbi.nlm.nih.gov/pubmed/37574754
http://dx.doi.org/10.1002/pro.4751

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