Knockdown of CXCL1 improves ACLF by reducing neutrophil recruitment to attenuate ROS production and hepatocyte apoptosis

BACKGROUND: Acute-on-chronic liver failure (ACLF) is an acute decompensated syndrome based on chronic liver disease, while neutrophil recruitment is the most critical early step. C-X-C motif chemokine ligand 1 (CXCL1), a cytokine that recruits neutrophils, was significantly upregulated in both ACLF...

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Detalles Bibliográficos
Autores principales: Tang, Shima, Zhang, Junlei, Zhang, Lingjian, Zhao, Yalei, Xiao, Lanlan, Zhang, Fen, Li, Qian, Yang, Ya, Liu, Qiuhong, Xu, Jinxian, Li, Lanjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503672/
https://www.ncbi.nlm.nih.gov/pubmed/37708451
http://dx.doi.org/10.1097/HC9.0000000000000257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503672/
https://www.ncbi.nlm.nih.gov/pubmed/37708451
http://dx.doi.org/10.1097/HC9.0000000000000257

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