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Inhibition of ATM-directed antiviral responses by HIV-1 Vif

Emerging evidence indicates that HIV-1 hijacks host DNA damage repair (DDR) pathways to facilitate multiple facets of virus replication. Canonically, HIV-1 engages proviral DDR responses through the accessory protein Vpr, which induces constitutive activation of DDR kinases ATM and ATR. However, in...

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Detalles Bibliográficos
Autores principales: Wong, Hoi Tong, Luperchio, Adeline M., Riley, Sean, Salamango, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503699/
https://www.ncbi.nlm.nih.gov/pubmed/37669285
http://dx.doi.org/10.1371/journal.ppat.1011634