A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer

Cancer stem cells drive tumor growth and survival via self-renewal and therapeutic resistance, but the upstream mechanisms are not well defined. In this issue of PLOS Biology, a study in colon cancer reveals a new signalling network that links epigenetic regulation to these phenotypes.

Detalles Bibliográficos
Autores principales: Hubert, Christopher G., Stauffer, Shaun R., Lathia, Justin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503703/
https://www.ncbi.nlm.nih.gov/pubmed/37713380
http://dx.doi.org/10.1371/journal.pbio.3002295
Descripción
Sumario:Cancer stem cells drive tumor growth and survival via self-renewal and therapeutic resistance, but the upstream mechanisms are not well defined. In this issue of PLOS Biology, a study in colon cancer reveals a new signalling network that links epigenetic regulation to these phenotypes.

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