A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer

Cancer stem cells drive tumor growth and survival via self-renewal and therapeutic resistance, but the upstream mechanisms are not well defined. In this issue of PLOS Biology, a study in colon cancer reveals a new signalling network that links epigenetic regulation to these phenotypes.

Detalles Bibliográficos
Autores principales: Hubert, Christopher G., Stauffer, Shaun R., Lathia, Justin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503703/
https://www.ncbi.nlm.nih.gov/pubmed/37713380
http://dx.doi.org/10.1371/journal.pbio.3002295
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author Hubert, Christopher G.
Stauffer, Shaun R.
Lathia, Justin D.
author_facet Hubert, Christopher G.
Stauffer, Shaun R.
Lathia, Justin D.
author_sort Hubert, Christopher G.
collection PubMed
description Cancer stem cells drive tumor growth and survival via self-renewal and therapeutic resistance, but the upstream mechanisms are not well defined. In this issue of PLOS Biology, a study in colon cancer reveals a new signalling network that links epigenetic regulation to these phenotypes.
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spelling pubmed-105037032023-09-16 A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer Hubert, Christopher G. Stauffer, Shaun R. Lathia, Justin D. PLoS Biol Primer Cancer stem cells drive tumor growth and survival via self-renewal and therapeutic resistance, but the upstream mechanisms are not well defined. In this issue of PLOS Biology, a study in colon cancer reveals a new signalling network that links epigenetic regulation to these phenotypes. Public Library of Science 2023-09-15 /pmc/articles/PMC10503703/ /pubmed/37713380 http://dx.doi.org/10.1371/journal.pbio.3002295 Text en © 2023 Hubert et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Primer
Hubert, Christopher G.
Stauffer, Shaun R.
Lathia, Justin D.
A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer
title A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer
title_full A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer
title_fullStr A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer
title_full_unstemmed A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer
title_short A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer
title_sort tox-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503703/
https://www.ncbi.nlm.nih.gov/pubmed/37713380
http://dx.doi.org/10.1371/journal.pbio.3002295
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