Nicotinamide restores tissue NAD(+) and improves survival in rodent models of cardiac arrest

Metabolic suppression in the ischemic heart is characterized by reduced levels of NAD(+) and ATP. Since NAD(+) is required for most metabolic processes that generate ATP, we hypothesized that nicotinamide restores ischemic tissue NAD(+) and improves cardiac function in cardiomyocytes and isolated he...

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Detalles Bibliográficos
Autores principales: Zhu, Xiangdong, Li, Jing, Wang, Huashan, Gasior, Filip M., Lee, Chunpei, Lin, Shaoxia, Justice, Cody N., O’Donnell, J. Michael, Vanden Hoek, Terry L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503771/
https://www.ncbi.nlm.nih.gov/pubmed/37713442
http://dx.doi.org/10.1371/journal.pone.0291598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503771/
https://www.ncbi.nlm.nih.gov/pubmed/37713442
http://dx.doi.org/10.1371/journal.pone.0291598

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