A phase I clinical trial of oncolytic adenovirus mediated suicide and interleukin-12 gene therapy in patients with recurrent localized prostate adenocarcinoma

In a phase I dose escalation and safety study (NCT02555397), a replication-competent oncolytic adenovirus expressing yCD, TK and hIL-12 (Ad5-yCD/mutTK(SR39)rep-hIL-12) was administered in 15 subjects with localized recurrent prostate cancer (T1c-T2) at increasing doses (1 × 10(10), to 1 × 10(12) vir...

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Detalles Bibliográficos
Autores principales: Nyati, Shyam, Stricker, Hans, Barton, Kenneth N., Li, Pin, Elshaikh, Mohamed, Ali, Haythem, Brown, Stephen L., Hwang, Clara, Peabody, James, Freytag, Svend O., Movsas, Benjamin, Siddiqui, Farzan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503775/
https://www.ncbi.nlm.nih.gov/pubmed/37713401
http://dx.doi.org/10.1371/journal.pone.0291315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503775/
https://www.ncbi.nlm.nih.gov/pubmed/37713401
http://dx.doi.org/10.1371/journal.pone.0291315

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