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Hemolysis dictates monocyte differentiation via two distinct pathways in sickle cell disease vaso-occlusion

Sickle cell disease (SCD) is a hereditary hemoglobinopathy characterized by painful vaso-occlusive crises (VOC) and chronic hemolysis. The mononuclear phagocyte system is pivotal to SCD pathophysiology, but the mechanisms governing monocyte/macrophage differentiation remain unknown. This study exami...

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Detalles Bibliográficos
Autores principales:	Liu, Yunfeng, Su, Shan, Shayo, Sarah, Bao, Weili, Pal, Mouli, Dou, Kai, Shi, Patricia A., Aygun, Banu, Campbell-Lee, Sally, Lobo, Cheryl A., Mendelson, Avital, An, Xiuli, Manwani, Deepa, Zhong, Hui, Yazdanbakhsh, Karina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503794/ https://www.ncbi.nlm.nih.gov/pubmed/37490346 http://dx.doi.org/10.1172/JCI172087

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