Allosteric modulator potentiates β(2)AR agonist–promoted bronchoprotection in asthma models

Asthma is a chronic inflammatory disease associated with episodic airway narrowing. Inhaled β(2)-adrenergic receptor (β(2)AR) agonists (β(2)-agonists) promote — with limited efficacy — bronchodilation in asthma. All β(2)-agonists are canonical orthosteric ligands that bind the same site as endogenou...

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Detalles Bibliográficos
Autores principales: Ahn, Seungkirl, Maarsingh, Harm, Walker, Julia K.L., Liu, Samuel, Hegde, Akhil, Sumajit, Hyeje C., Kahsai, Alem W., Lefkowitz, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503797/
https://www.ncbi.nlm.nih.gov/pubmed/37432742
http://dx.doi.org/10.1172/JCI167337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503797/
https://www.ncbi.nlm.nih.gov/pubmed/37432742
http://dx.doi.org/10.1172/JCI167337

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