Tregs with an MHC class II peptide–specific chimeric antigen receptor prevent autoimmune diabetes in mice

Adoptive immunotherapy with Tregs is a promising approach for preventing or treating type 1 diabetes. Islet antigen–specific Tregs have more potent therapeutic effects than polyclonal cells, but their low frequency is a barrier for clinical application. To generate Tregs that recognize islet antigen...

Descripción completa

Detalles Bibliográficos
Autores principales: Spanier, Justin A., Fung, Vivian, Wardell, Christine M., Alkhatib, Mohannad H., Chen, Yixin, Swanson, Linnea A., Dwyer, Alexander J., Weno, Matthew E., Silva, Nubia, Mitchell, Jason S., Orban, Paul C., Mojibian, Majid, Verchere, C. Bruce, Fife, Brian T., Levings, Megan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503798/
https://www.ncbi.nlm.nih.gov/pubmed/37561596
http://dx.doi.org/10.1172/JCI168601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503798/
https://www.ncbi.nlm.nih.gov/pubmed/37561596
http://dx.doi.org/10.1172/JCI168601

Ejemplares similares