Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation

Expanding β cell mass is a critical goal in the fight against diabetes. CDK4, an extensively characterized cell cycle activator, is required to establish and maintain β cell number. β cell failure in the IRS2-deletion mouse type 2 diabetes model is, in part, due to loss of CDK4 regulator cyclin D2....

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Detalles Bibliográficos
Autores principales: Stamateris, Rachel E., Landa-Galvan, Huguet V., Sharma, Rohit B., Darko, Christine, Redmond, David, Rane, Sushil G., Alonso, Laura C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503800/
https://www.ncbi.nlm.nih.gov/pubmed/37712417
http://dx.doi.org/10.1172/JCI166490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503800/
https://www.ncbi.nlm.nih.gov/pubmed/37712417
http://dx.doi.org/10.1172/JCI166490

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