Tumors produce glucocorticoids by metabolite recycling, not synthesis, and activate Tregs to promote growth

Glucocorticoids are steroid hormones with potent immunosuppressive properties. Their primary source is the adrenals, where they are generated via de novo synthesis from cholesterol. In addition, many tissues have a recycling pathway in which glucocorticoids are regenerated from inactive metabolites...

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Detalles Bibliográficos
Autores principales: Taves, Matthew D., Otsuka, Shizuka, Taylor, Michaela A., Donahue, Kaitlynn M., Meyer, Thomas J., Cam, Margaret C., Ashwell, Jonathan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503810/
https://www.ncbi.nlm.nih.gov/pubmed/37471141
http://dx.doi.org/10.1172/JCI164599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503810/
https://www.ncbi.nlm.nih.gov/pubmed/37471141
http://dx.doi.org/10.1172/JCI164599

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