Tau fibrils induce glial inflammation and neuropathology via TLR2 in Alzheimer’s disease–related mouse models

Glial activation and inflammation coincide with neurofibrillary tangle (NFT) formation in neurons. However, the mechanism behind the interaction between tau fibrils and glia is poorly understood. Here, we found that tau preformed fibrils (PFFs) caused induction of inflammation in microglia by specif...

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Detalles Bibliográficos
Autores principales: Dutta, Debashis, Jana, Malabendu, Paidi, Ramesh Kumar, Majumder, Moumita, Raha, Sumita, Dasarathy, Sridevi, Pahan, Kalipada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503811/
https://www.ncbi.nlm.nih.gov/pubmed/37552543
http://dx.doi.org/10.1172/JCI161987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503811/
https://www.ncbi.nlm.nih.gov/pubmed/37552543
http://dx.doi.org/10.1172/JCI161987

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