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ASCL2 induces an immune excluded microenvironment by activating cancer-associated fibroblasts in microsatellite stable colorectal cancer

Proficient mismatch repair or microsatellite stable (pMMR/MSS) colorectal cancers (CRCs) are vastly outnumbered by deficient mismatch repair or microsatellite instability-high (dMMR/MSI-H) tumors and lack a response to immune checkpoint inhibitors (ICIs). In this study, we reported two distinct expr...

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Detalles Bibliográficos
Autores principales: Zhang, Dan, Ni, Qi-Qi, Liang, Qiao-Yan, He, Li-Ling, Qiu, Bo-Wen, Zhang, Ling-Jie, Mou, Ting-Yu, Le, Chen-Chen, Huang, Yuan, Li, Ting-Ting, Wang, Shu-Yang, Ding, Yan-Qing, Jiao, Hong-Li, Ye, Ya-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504082/
https://www.ncbi.nlm.nih.gov/pubmed/37591954
http://dx.doi.org/10.1038/s41388-023-02806-3