Cysteine conjugates of acetaminophen and p-aminophenol are potent inducers of cellular impairment in human proximal tubular kidney HK-2 cells

Acetaminophen (APAP) belong among the most used analgesics and antipyretics. It is structurally derived from p-aminophenol (PAP), a potent inducer of kidney toxicity. Both compounds can be metabolized to oxidation products and conjugated with glutathione. The glutathione-conjugates can be cleaved to...

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Detalles Bibliográficos
Autores principales: Rousar, Tomas, Handl, Jiri, Capek, Jan, Nyvltova, Pavlina, Rousarova, Erika, Kubat, Miroslav, Smid, Lenka, Vanova, Jana, Malinak, David, Musilek, Kamil, Cesla, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Organ Toxicity and Mechanisms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504157/
https://www.ncbi.nlm.nih.gov/pubmed/37639014
http://dx.doi.org/10.1007/s00204-023-03569-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504157/
https://www.ncbi.nlm.nih.gov/pubmed/37639014
http://dx.doi.org/10.1007/s00204-023-03569-2

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