Application of high throughput in vitro metabolomics for hepatotoxicity mode of action characterization and mechanistic-anchored point of departure derivation: a case study with nitrofurantoin

Omics techniques have been increasingly recognized as promising tools for Next Generation Risk Assessment. Targeted metabolomics offer the advantage of providing readily interpretable mechanistic information about perturbed biological pathways. In this study, a high-throughput LC–MS/MS-based broad t...

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Detalles Bibliográficos
Autores principales: Ramirez-Hincapie, Sabina, Birk, Barbara, Ternes, Philipp, Giri, Varun, Zickgraf, Franziska Maria, Haake, Volker, Herold, Michael, Kamp, Hennicke, Driemert, Peter, Landsiedel, Robert, Richling, Elke, Funk-Weyer, Dorothee, van Ravenzwaay, Bennard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Toxicogenomics and Omics Technologies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504224/
https://www.ncbi.nlm.nih.gov/pubmed/37665362
http://dx.doi.org/10.1007/s00204-023-03572-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504224/
https://www.ncbi.nlm.nih.gov/pubmed/37665362
http://dx.doi.org/10.1007/s00204-023-03572-7

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