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Application of high throughput in vitro metabolomics for hepatotoxicity mode of action characterization and mechanistic-anchored point of departure derivation: a case study with nitrofurantoin
Omics techniques have been increasingly recognized as promising tools for Next Generation Risk Assessment. Targeted metabolomics offer the advantage of providing readily interpretable mechanistic information about perturbed biological pathways. In this study, a high-throughput LC–MS/MS-based broad t...
Autores principales: | Ramirez-Hincapie, Sabina, Birk, Barbara, Ternes, Philipp, Giri, Varun, Zickgraf, Franziska Maria, Haake, Volker, Herold, Michael, Kamp, Hennicke, Driemert, Peter, Landsiedel, Robert, Richling, Elke, Funk-Weyer, Dorothee, van Ravenzwaay, Bennard |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504224/ https://www.ncbi.nlm.nih.gov/pubmed/37665362 http://dx.doi.org/10.1007/s00204-023-03572-7 |
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