A microprotein N1DARP encoded by LINC00261 promotes Notch1 intracellular domain (N1ICD) degradation via disrupting USP10-N1ICD interaction to inhibit chemoresistance in Notch1-hyperactivated pancreatic cancer

The extensively activated Notch signaling pathway in pancreatic cancer cells is important in carcinogenesis, chemoresistance, and recurrence. Targeting this pathway is a promising therapeutic strategy for pancreatic cancer; however, few successful approaches have been reported, and currently used mo...

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Detalles Bibliográficos
Autores principales: Zhai, Shuyu, Lin, Jiewei, Ji, Yuchen, Zhang, Ronghao, Zhang, Zehui, Cao, Yizhi, Liu, Yang, Tang, Xiaomei, Liu, Jia, Liu, Pengyi, Lin, Jiayu, Li, Fanlu, Li, Hongzhe, Shi, Yusheng, Fu, Da, Deng, Xiaxing, Shen, Baiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504324/
https://www.ncbi.nlm.nih.gov/pubmed/37714834
http://dx.doi.org/10.1038/s41421-023-00592-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504324/
https://www.ncbi.nlm.nih.gov/pubmed/37714834
http://dx.doi.org/10.1038/s41421-023-00592-6

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