Inducing multiple nicks promotes interhomolog homologous recombination to correct heterozygous mutations in somatic cells

CRISPR/Cas9-mediated gene editing has great potential utility for treating genetic diseases. However, its therapeutic applications are limited by unintended genomic alterations arising from DNA double-strand breaks and random integration of exogenous DNA. In this study, we propose NICER, a method fo...

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Detalles Bibliográficos
Autores principales: Tomita, Akiko, Sasanuma, Hiroyuki, Owa, Tomoo, Nakazawa, Yuka, Shimada, Mayuko, Fukuoka, Takahiro, Ogi, Tomoo, Nakada, Shinichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504326/
https://www.ncbi.nlm.nih.gov/pubmed/37714828
http://dx.doi.org/10.1038/s41467-023-41048-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504326/
https://www.ncbi.nlm.nih.gov/pubmed/37714828
http://dx.doi.org/10.1038/s41467-023-41048-5

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