The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism

Arachidonic and adrenic acids in the membrane play key roles in ferroptosis. Here, we reveal that lipoprotein-associated phospholipase A2 (Lp-PLA2) controls intracellular phospholipid metabolism and contributes to ferroptosis resistance. A metabolic drug screen reveals that darapladib, an inhibitor...

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Detalles Bibliográficos
Autores principales: Oh, Mihee, Jang, Seo Young, Lee, Ji-Yoon, Kim, Jong Woo, Jung, Youngae, Kim, Jiwoo, Seo, Jinho, Han, Tae-Su, Jang, Eunji, Son, Hye Young, Kim, Dain, Kim, Min Wook, Park, Jin-Sung, Song, Kwon-Ho, Oh, Kyoung-Jin, Kim, Won Kon, Bae, Kwang-Hee, Huh, Yong-Min, Kim, Soon Ha, Kim, Doyoun, Han, Baek-Soo, Lee, Sang Chul, Hwang, Geum-Sook, Lee, Eun-Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504358/
https://www.ncbi.nlm.nih.gov/pubmed/37714840
http://dx.doi.org/10.1038/s41467-023-41462-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504358/
https://www.ncbi.nlm.nih.gov/pubmed/37714840
http://dx.doi.org/10.1038/s41467-023-41462-9

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