Beta(1)-Adrenergic Receptor Cleavage and Regulation by Elastase

The decrease in β(1)-adrenergic receptor responsiveness in heart failure is attributed conventionally to agonist-dependent desensitization. We identify elastase-dependent β(1)-adrenergic receptor cleavage as a novel proteolytic mechanism that disrupts β(1)-adrenergic receptor responsiveness in the s...

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Detalles Bibliográficos
Autores principales: Zhu, Jing, Steinberg, Susan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Research - Preclinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504397/
https://www.ncbi.nlm.nih.gov/pubmed/37719436
http://dx.doi.org/10.1016/j.jacbts.2023.02.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504397/
https://www.ncbi.nlm.nih.gov/pubmed/37719436
http://dx.doi.org/10.1016/j.jacbts.2023.02.002

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