Cargando…
Beta(1)-Adrenergic Receptor Cleavage and Regulation by Elastase
The decrease in β(1)-adrenergic receptor responsiveness in heart failure is attributed conventionally to agonist-dependent desensitization. We identify elastase-dependent β(1)-adrenergic receptor cleavage as a novel proteolytic mechanism that disrupts β(1)-adrenergic receptor responsiveness in the s...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504397/ https://www.ncbi.nlm.nih.gov/pubmed/37719436 http://dx.doi.org/10.1016/j.jacbts.2023.02.002 |
| Sumario: | The decrease in β(1)-adrenergic receptor responsiveness in heart failure is attributed conventionally to agonist-dependent desensitization. We identify elastase-dependent β(1)-adrenergic receptor cleavage as a novel proteolytic mechanism that disrupts β(1)-adrenergic receptor responsiveness in the setting of tissue injury or inflammation. |
|---|