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Beta(1)-Adrenergic Receptor Cleavage and Regulation by Elastase
The decrease in β(1)-adrenergic receptor responsiveness in heart failure is attributed conventionally to agonist-dependent desensitization. We identify elastase-dependent β(1)-adrenergic receptor cleavage as a novel proteolytic mechanism that disrupts β(1)-adrenergic receptor responsiveness in the s...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504397/ https://www.ncbi.nlm.nih.gov/pubmed/37719436 http://dx.doi.org/10.1016/j.jacbts.2023.02.002 |
| _version_ | 1785106716404219904 |
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| author | Zhu, Jing Steinberg, Susan F. |
| author_facet | Zhu, Jing Steinberg, Susan F. |
| author_sort | Zhu, Jing |
| collection | PubMed |
| description | The decrease in β(1)-adrenergic receptor responsiveness in heart failure is attributed conventionally to agonist-dependent desensitization. We identify elastase-dependent β(1)-adrenergic receptor cleavage as a novel proteolytic mechanism that disrupts β(1)-adrenergic receptor responsiveness in the setting of tissue injury or inflammation. |
| format | Online Article Text |
| id | pubmed-10504397 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-105043972023-09-17 Beta(1)-Adrenergic Receptor Cleavage and Regulation by Elastase Zhu, Jing Steinberg, Susan F. JACC Basic Transl Sci Original Research - Preclinical The decrease in β(1)-adrenergic receptor responsiveness in heart failure is attributed conventionally to agonist-dependent desensitization. We identify elastase-dependent β(1)-adrenergic receptor cleavage as a novel proteolytic mechanism that disrupts β(1)-adrenergic receptor responsiveness in the setting of tissue injury or inflammation. Elsevier 2023-05-17 /pmc/articles/PMC10504397/ /pubmed/37719436 http://dx.doi.org/10.1016/j.jacbts.2023.02.002 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Original Research - Preclinical Zhu, Jing Steinberg, Susan F. Beta(1)-Adrenergic Receptor Cleavage and Regulation by Elastase |
| title | Beta(1)-Adrenergic Receptor Cleavage and Regulation by Elastase |
| title_full | Beta(1)-Adrenergic Receptor Cleavage and Regulation by Elastase |
| title_fullStr | Beta(1)-Adrenergic Receptor Cleavage and Regulation by Elastase |
| title_full_unstemmed | Beta(1)-Adrenergic Receptor Cleavage and Regulation by Elastase |
| title_short | Beta(1)-Adrenergic Receptor Cleavage and Regulation by Elastase |
| title_sort | beta(1)-adrenergic receptor cleavage and regulation by elastase |
| topic | Original Research - Preclinical |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504397/ https://www.ncbi.nlm.nih.gov/pubmed/37719436 http://dx.doi.org/10.1016/j.jacbts.2023.02.002 |
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