Incorporation of noncanonical base Z yields modified mRNA with minimal immunogenicity and improved translational capacity in mammalian cells

Chemically modified mRNAs hold great potential for therapeutic applications in vivo. Currently, the base modification scheme largely preserves the canonical Watson-Crick base pairing, thus missing one mode of mRNA modulation by altering its secondary structure. Here we report the incorporation of ba...

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Detalles Bibliográficos
Autores principales: Zhang, Meng, Singh, Nilmani, Ehmann, Mary Elisabeth, Zheng, Lining, Zhao, Huimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504480/
https://www.ncbi.nlm.nih.gov/pubmed/37720088
http://dx.doi.org/10.1016/j.isci.2023.107739

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504480/
https://www.ncbi.nlm.nih.gov/pubmed/37720088
http://dx.doi.org/10.1016/j.isci.2023.107739

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