Cargando…

Incorporation of noncanonical base Z yields modified mRNA with minimal immunogenicity and improved translational capacity in mammalian cells

Chemically modified mRNAs hold great potential for therapeutic applications in vivo. Currently, the base modification scheme largely preserves the canonical Watson-Crick base pairing, thus missing one mode of mRNA modulation by altering its secondary structure. Here we report the incorporation of ba...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Meng, Singh, Nilmani, Ehmann, Mary Elisabeth, Zheng, Lining, Zhao, Huimin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504480/ https://www.ncbi.nlm.nih.gov/pubmed/37720088 http://dx.doi.org/10.1016/j.isci.2023.107739

Ejemplares similares

Minimizing the Anticodon-Recognized Loop of Methanococcus jannaschii Tyrosyl-tRNA Synthetase to Improve the Efficiency of Incorporating Noncanonical Amino Acids
por: Hu, Zhiyang, et al.
Publicado: (2023)

Aldolase A Accelerates Cancer Progression by Modulating mRNA Translation and Protein Biosynthesis via Noncanonical Mechanisms
por: Song, Junjiao, et al.
Publicado: (2023)

Residue-specific Incorporation of Noncanonical Amino Acids into Model Proteins Using an Escherichia coli Cell-free Transcription-translation System
por: Worst, Emanuel G., et al.
Publicado: (2016)

Noncanonical Functions and Cellular Dynamics of the Mammalian Signal Recognition Particle Components
por: Faoro, Camilla, et al.
Publicado: (2021)

Exploring the Immunogenicity of Noncanonical HLA-I Tumor Ligands Identified through Proteogenomics
por: Lozano-Rabella, Maria, et al.
Publicado: (2023)

Rationally evolving tRNA(Pyl) for efficient incorporation of noncanonical amino acids
por: Fan, Chenguang, et al.
Publicado: (2015)

Efficient Selection Scheme for Incorporating Noncanonical Amino Acids Into Proteins in Saccharomyces cerevisiae
por: Tan, Linzhi, et al.
Publicado: (2020)

Incorporation of Noncanonical Amino Acids into Rosetta and Use in Computational Protein-Peptide Interface Design
por: Renfrew, P. Douglas, et al.
Publicado: (2012)

Translation landscape of SARS-CoV-2 noncanonical subgenomic RNAs
por: Wu, Kai, et al.
Publicado: (2022)

Defining the current scope and limitations of dual noncanonical amino acid mutagenesis in mammalian cells
por: Zheng, Yunan, et al.
Publicado: (2017)

A noncanonical RNA-binding domain of the fragile X protein, FMRP, elicits translational repression independent of mRNA G-quadruplexes
por: Scarpitti, MaKenzie R., et al.
Publicado: (2022)

Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation
por: Anderson, Bart R., et al.
Publicado: (2010)

A Modular Strategy for Expanding Electron-Sink Capacity in Noncanonical Cluster Assemblies
por: Mai, Yume, et al.
Publicado: (2021)

The Role of Canonical and Noncanonical Pre-mRNA Splicing in Plant Stress Responses
por: Dubrovina, A. S., et al.
Publicado: (2013)

Assessment of Selective mRNA Translation in Mammalian Cells by Polysome Profiling
por: Faye, Mame Daro, et al.
Publicado: (2014)

Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes
por: Shao, Sichen, et al.
Publicado: (2016)

The Paradoxes of Viral mRNA Translation during Mammalian Orthoreovirus Infection
por: Guo, Yingying, et al.
Publicado: (2021)

Forced Ambiguity of the Leucine Codons for Multiple-Site-Specific Incorporation of a Noncanonical Amino Acid
por: Kwon, Inchan, et al.
Publicado: (2016)

Selection, Addiction and Catalysis: Emerging Trends for the Incorporation of Noncanonical Amino Acids into Peptides and Proteins in Vivo
por: Mayer, Clemens
Publicado: (2019)

Folding Assessment of Incorporation of Noncanonical Amino Acids Facilitates Expansion of Functional‐Group Diversity for Enzyme Engineering
por: Drienovská, Ivana, et al.
Publicado: (2020)

Evaluating Translational Efficiency of Noncanonical Amino Acids to Inform the Design of Druglike Peptide Libraries
por: Chan, Alix I, et al.
Publicado: (2023)

Noncanonical hamiltonian mechanics
por: Littlejohn, R G
Publicado: (1986)

Noncanonical Reactions of Flavoenzymes
por: Sobrado, Pablo
Publicado: (2012)

Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine
por: Palomar-Siles, Mireia, et al.
Publicado: (2022)

Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids
por: Martin, Rey W., et al.
Publicado: (2018)

Viral protein X reduces the incorporation of mutagenic noncanonical rNTPs during lentivirus reverse transcription in macrophages
por: Oo, Adrian, et al.
Publicado: (2020)

Crucial Optimization of Translational Components towards Efficient Incorporation of Unnatural Amino Acids into Proteins in Mammalian Cells
por: Xiang, Liang, et al.
Publicado: (2013)

Quantitative analysis of mRNA translation in mammalian spermatogenic cells with sucrose and Nycodenz gradients
por: Kleene, Kenneth C, et al.
Publicado: (2010)

Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA
por: Powers, Kyle T, et al.
Publicado: (2021)

Chemo‐Enzymatic Modification of the 5′ Cap Maintains Translation and Increases Immunogenic Properties of mRNA
por: van Dülmen, Melissa, et al.
Publicado: (2021)

Discovery of noncanonical translation initiation sites through mass spectrometric analysis of protein N termini
por: Na, Chan Hyun, et al.
Publicado: (2018)

Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring
por: Cagnetta, Roberta, et al.
Publicado: (2019)

Noncanonical Roles of RAD51
por: Thomas, Mélissa, et al.
Publicado: (2023)

Incorporation of membrane-bound, mammalian-derived immunomodulatory proteins into influenza whole virus vaccines boosts immunogenicity and protection against lethal challenge
por: Herbert, Andrew S, et al.
Publicado: (2009)

Influenza A virus utilizes noncanonical cap-snatching to diversify its mRNA/ncRNA
por: Li, Lichao, et al.
Publicado: (2020)

Reservoir capacity and yield /
por: McMahon, T. A.
Publicado: (1978)

Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex
por: Salamon, Iva, et al.
Publicado: (2023)

Ire1-mediated decay in mammalian cells relies on mRNA sequence, structure, and translational status
por: Moore, Kristin, et al.
Publicado: (2015)

Noncanonical NF-κB in Cancer
por: Tegowski, Matthew, et al.
Publicado: (2018)

Noncanonical Ion Channel Behaviour in Pain
por: Ciotu, Cosmin I., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_8nuqfmnseqfmg64qng7ejf4d0o