Highly sensitive visual restoration and protection via ectopic expression of chimeric rhodopsin in mice

Photoreception requires amplification by mammalian rhodopsin through G protein activation, which requires a visual cycle. To achieve this in retinal gene therapy, we incorporated human rhodopsin cytoplasmic loops into Gloeobacter rhodopsin, thereby generating Gloeobacter and human chimeric rhodopsin...

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Detalles Bibliográficos
Autores principales: Katada, Yusaku, Yoshida, Kazuho, Serizawa, Naho, Lee, Deokho, Kobayashi, Kenta, Negishi, Kazuno, Okano, Hideyuki, Kandori, Hideki, Tsubota, Kazuo, Kurihara, Toshihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504486/
https://www.ncbi.nlm.nih.gov/pubmed/37720108
http://dx.doi.org/10.1016/j.isci.2023.107716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504486/
https://www.ncbi.nlm.nih.gov/pubmed/37720108
http://dx.doi.org/10.1016/j.isci.2023.107716

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