Cargando…

CGK733 alleviates ovariectomy-induced bone loss through blocking RANKL-mediated Ca(2+) oscillations and NF-κB/MAPK signaling pathways

Osteoporosis is a prevalent systemic metabolic disease in modern society, in which patients often suffer from bone loss due to over-activation of osteoclasts. Currently, amelioration of bone loss through modulation of osteoclast activity is a major therapeutic strategy. Ataxia telangiectasia mutated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Minglian, Song, Dezhi, Xie, Xiaoxiao, Qin, Yiwu, Huang, Jian, Wang, Chaofeng, Chen, Junchun, Su, Yuangang, Xu, Jiake, Zhao, Jinmin, Liu, Qian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504545/ https://www.ncbi.nlm.nih.gov/pubmed/37720109 http://dx.doi.org/10.1016/j.isci.2023.107760

Ejemplares similares

Casticin suppresses RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating the AKT/ERK and NF-κB signaling pathways
por: Yang, Fan, et al.
Publicado: (2023)

Vindoline Inhibits RANKL-Induced Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss in Mice
por: Zhan, Yunfei, et al.
Publicado: (2020)

The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation
por: Alao, John P, et al.
Publicado: (2009)

Myrislignan targets extracellular signal-regulated kinase (ERK) and modulates mitochondrial function to dampen osteoclastogenesis and ovariectomy-induced osteoporosis
por: Yang, Tao, et al.
Publicado: (2023)

PERK/CHOP contributes to the CGK733-induced vesicular calcium sequestration which is accompanied by non-apoptotic cell death
por: Wang, Yufeng, et al.
Publicado: (2015)

Anti-Osteoclast Effect of Exportin-1 Inhibitor Eltanexor on Osteoporosis Depends on Nuclear Accumulation of IκBα–NF-κB p65 Complex
por: Chen, Junchun, et al.
Publicado: (2022)

Andrographolide Inhibits Ovariectomy-Induced Bone Loss via the Suppression of RANKL Signaling Pathways
por: Wang, Tao, et al.
Publicado: (2015)

Sesamolin Protects Mice From Ovariectomized Bone Loss by Inhibiting Osteoclastogenesis and RANKL-Mediated NF-κB and MAPK Signaling Pathways
por: Yang, Xue, et al.
Publicado: (2021)

BCI Suppresses RANKL-Mediated Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss
por: Cai, Chenhui, et al.
Publicado: (2021)

Interaction of cCMP with the cGK, cAK and MAPK Kinases in Murine Tissues
por: Wolfertstetter, Stefanie, et al.
Publicado: (2015)

Interaction of cCMP with the cGK, cAK and MAPK kinases in murine tissues
por: Wolfertstetter, Stefanie, et al.
Publicado: (2015)

Evodiamine inhibits RANKL‐induced osteoclastogenesis and prevents ovariectomy‐induced bone loss in mice
por: Jin, Haiming, et al.
Publicado: (2018)

Inhibiting Monoacylglycerol Lipase Suppresses RANKL-Induced Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss
por: Liu, Hui, et al.
Publicado: (2021)

Berbamine inhibits RANKL- and M-CSF-mediated osteoclastogenesis and alleviates ovariectomy-induced bone loss
por: Qi, Guobin, et al.
Publicado: (2022)

CGK733-induced LC3 II formation is positively associated with the expression of cyclin-dependent kinase inhibitor p21(Waf1/Cip1) through modulation of the AMPK and PERK/CHOP signaling pathways
por: Wang, Yufeng, et al.
Publicado: (2015)

Betulinic Acid Protects From Bone Loss in Ovariectomized Mice and Suppresses RANKL-Associated Osteoclastogenesis by Inhibiting the MAPK and NFATc1 Pathways
por: Wei, Jiyong, et al.
Publicado: (2020)

Icaritin ameliorates RANKL-mediated osteoclastogenesis and ovariectomy-induced osteoporosis
por: Huang, Jun-ming, et al.
Publicado: (2023)

Amyloid β Peptide Enhances RANKL-Induced Osteoclast Activation through NF-κB, ERK, and Calcium Oscillation Signaling
por: Li, Shangfu, et al.
Publicado: (2016)

Functional dissection of the cGK substrate IRAG using transgenic models
por: Schlossmann, Jens, et al.
Publicado: (2009)

Parkin Inhibits RANKL-Induced Osteoclastogenesis and Ovariectomy-Induced Bone Loss
por: Hou, Weiduo, et al.
Publicado: (2022)

Transepithelial Fluid and Salt Re-Absorption Regulated by cGK2 Signals
por: Chang, Jianjun, et al.
Publicado: (2018)

Isoliensinine Suppresses Osteoclast Formation Through NF-κB Signaling Pathways and Relieves Ovariectomy-Induced Bone Loss
por: Liu, Huijiang, et al.
Publicado: (2022)

Berberine Sulfate Attenuates Osteoclast Differentiation through RANKL Induced NF-κB and NFAT Pathways
por: Zhou, Lin, et al.
Publicado: (2015)

Cytisine attenuates bone loss of ovariectomy mouse by preventing RANKL‐induced osteoclastogenesis
por: Qian, Zhi, et al.
Publicado: (2020)

Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss
por: Qi, Dahu, et al.
Publicado: (2021)

Role of Mast-Cell-Derived RANKL in Ovariectomy-Induced Bone Loss in Mice
por: Fischer, Verena, et al.
Publicado: (2023)

Beneficial effect of pristimerin against the development of osteoporosis in ovariectomy-induced osteoporosis rats by the RANKL/TRAF6/NF-κB pathway
por: Xu, Wei, et al.
Publicado: (2019)

Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
por: Xiong, Jinhu, et al.
Publicado: (2018)

Anti-Osteoporotic Effects of n-trans-Hibiscusamide and Its Derivative Alleviate Ovariectomy-Induced Bone Loss in Mice by Regulating RANKL-Induced Signaling
por: Lim, Hyung Jin, et al.
Publicado: (2021)

KMUP-1 Suppresses RANKL-Induced Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss: Roles of MAPKs, Akt, NF-κB and Calcium/Calcineurin/NFATc1 Pathways
por: Liou, Shu-Fen, et al.
Publicado: (2013)

Cytochalasin Z11 inhibits RANKL-induced osteoclastogenesis via suppressing NFATc1 activation
por: Wang, Lu, et al.
Publicado: (2019)

Obacunone targets macrophage migration inhibitory factor (MIF) to impede osteoclastogenesis and alleviate ovariectomy-induced bone loss
por: He, Jianbo, et al.
Publicado: (2023)

Fangchinoline protects against bone loss in OVX mice via inhibiting osteoclast formation, bone resorption and RANKL-induced signaling
por: Zhou, Lin, et al.
Publicado: (2020)

Celastrol Attenuates RANKL-Induced Osteoclastogenesis in vitro and Reduces Titanium Particle-Induced Osteolysis and Ovariectomy-Induced Bone Loss in vivo
por: Xu, Qiang, et al.
Publicado: (2021)

Pristimerin Protects Against OVX-Mediated Bone Loss by Attenuating Osteoclast Formation and Activity via Inhibition of RANKL-Mediated Activation of NF-κB and ERK Signaling Pathways
por: Li, Xuedong, et al.
Publicado: (2021)

Fumitremorgin C Attenuates Osteoclast Formation and Function via Suppressing RANKL-Induced Signaling Pathways
por: Yuan, Yu, et al.
Publicado: (2020)

CYT387, a JAK-Specific Inhibitor Impedes Osteoclast Activity and Oophorectomy-Induced Osteoporosis via Modulating RANKL and ROS Signaling Pathways
por: Li, Jing, et al.
Publicado: (2022)

Theaflavin-3, 3′-Digallate Suppresses RANKL-Induced Osteoclastogenesis and Attenuates Ovariectomy-Induced Bone Loss in Mice
por: Ai, Zexin, et al.
Publicado: (2020)

Water Extract of Fritillariae thunbergii Bulbus Inhibits RANKL-Mediated Osteoclastogenesis and Ovariectomy-Induced Trabecular Bone Loss
por: Shim, Ki-Shuk, et al.
Publicado: (2021)

Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6/ROS-dependent MAPK/NF-κB signaling pathways
por: Xiao, Long, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_5g8au43mkvtaeoerdkfhufkpu0