Better together: Non-additive interactions between schizophrenia risk genes

Zhang, Zhang, Forrest et al combine allele-specific open chromatin (ASoC) mapping and CRISPR-editing to evaluate the functional impact of schizophrenia risk variants on human neuronal gene expression, synaptic development, and function. In doing so, they uncover surprising non-additive effects betwe...

Descripción completa

Detalles Bibliográficos
Autores principales: Deans, P.J. Michael, Brennand, Kristen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Preview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504666/
https://www.ncbi.nlm.nih.gov/pubmed/37719145
http://dx.doi.org/10.1016/j.xgen.2023.100403
_version_ 1785106775422271488
author Deans, P.J. Michael
Brennand, Kristen J.
author_facet Deans, P.J. Michael
Brennand, Kristen J.
author_sort Deans, P.J. Michael
collection PubMed
description Zhang, Zhang, Forrest et al combine allele-specific open chromatin (ASoC) mapping and CRISPR-editing to evaluate the functional impact of schizophrenia risk variants on human neuronal gene expression, synaptic development, and function. In doing so, they uncover surprising non-additive effects between target genes regulated by the same risk variant.
format Online
Article
Text
id pubmed-10504666
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-105046662023-09-17 Better together: Non-additive interactions between schizophrenia risk genes Deans, P.J. Michael Brennand, Kristen J. Cell Genom Preview Zhang, Zhang, Forrest et al combine allele-specific open chromatin (ASoC) mapping and CRISPR-editing to evaluate the functional impact of schizophrenia risk variants on human neuronal gene expression, synaptic development, and function. In doing so, they uncover surprising non-additive effects between target genes regulated by the same risk variant. Elsevier 2023-09-13 /pmc/articles/PMC10504666/ /pubmed/37719145 http://dx.doi.org/10.1016/j.xgen.2023.100403 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preview
Deans, P.J. Michael
Brennand, Kristen J.
Better together: Non-additive interactions between schizophrenia risk genes
title Better together: Non-additive interactions between schizophrenia risk genes
title_full Better together: Non-additive interactions between schizophrenia risk genes
title_fullStr Better together: Non-additive interactions between schizophrenia risk genes
title_full_unstemmed Better together: Non-additive interactions between schizophrenia risk genes
title_short Better together: Non-additive interactions between schizophrenia risk genes
title_sort better together: non-additive interactions between schizophrenia risk genes
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504666/
https://www.ncbi.nlm.nih.gov/pubmed/37719145
http://dx.doi.org/10.1016/j.xgen.2023.100403
work_keys_str_mv AT deanspjmichael bettertogethernonadditiveinteractionsbetweenschizophreniariskgenes
AT brennandkristenj bettertogethernonadditiveinteractionsbetweenschizophreniariskgenes

Ejemplares similares