Polygenic regression uncovers trait-relevant cellular contexts through pathway activation transformation of single-cell RNA sequencing data

Advances in single-cell RNA sequencing (scRNA-seq) techniques have accelerated functional interpretation of disease-associated variants discovered from genome-wide association studies (GWASs). However, identification of trait-relevant cell populations is often impeded by inherent technical noise and...

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Detalles Bibliográficos
Autores principales: Ma, Yunlong, Deng, Chunyu, Zhou, Yijun, Zhang, Yaru, Qiu, Fei, Jiang, Dingping, Zheng, Gongwei, Li, Jingjing, Shuai, Jianwei, Zhang, Yan, Yang, Jian, Su, Jianzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504677/
https://www.ncbi.nlm.nih.gov/pubmed/37719150
http://dx.doi.org/10.1016/j.xgen.2023.100383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504677/
https://www.ncbi.nlm.nih.gov/pubmed/37719150
http://dx.doi.org/10.1016/j.xgen.2023.100383

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