A least-squares-fitting procedure for an efficient preclinical ranking of passive transport across the blood–brain barrier endothelium

The treatment of various disorders of the central nervous system (CNS) is often impeded by the limited brain exposure of drugs, which is regulated by the human blood–brain barrier (BBB). The screening of lead compounds for CNS penetration is challenging due to the biochemical complexity of the BBB,...

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Detalles Bibliográficos
Autores principales: Jorgensen, Christian, Troendle, Evan P., Ulmschneider, Jakob P., Searson, Peter C., Ulmschneider, Martin B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505096/
https://www.ncbi.nlm.nih.gov/pubmed/37573260
http://dx.doi.org/10.1007/s10822-023-00525-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505096/
https://www.ncbi.nlm.nih.gov/pubmed/37573260
http://dx.doi.org/10.1007/s10822-023-00525-1

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