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A least-squares-fitting procedure for an efficient preclinical ranking of passive transport across the blood–brain barrier endothelium
The treatment of various disorders of the central nervous system (CNS) is often impeded by the limited brain exposure of drugs, which is regulated by the human blood–brain barrier (BBB). The screening of lead compounds for CNS penetration is challenging due to the biochemical complexity of the BBB,...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505096/ https://www.ncbi.nlm.nih.gov/pubmed/37573260 http://dx.doi.org/10.1007/s10822-023-00525-1 |