Performance of tumour microenvironment deconvolution methods in breast cancer using single-cell simulated bulk mixtures

Cells within the tumour microenvironment (TME) can impact tumour development and influence treatment response. Computational approaches have been developed to deconvolve the TME from bulk RNA-seq. Using scRNA-seq profiling from breast tumours we simulate thousands of bulk mixtures, representing tumo...

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Detalles Bibliográficos
Autores principales: Tran, Khoa A., Addala, Venkateswar, Johnston, Rebecca L., Lovell, David, Bradley, Andrew, Koufariotis, Lambros T., Wood, Scott, Wu, Sunny Z., Roden, Daniel, Al-Eryani, Ghamdan, Swarbrick, Alexander, Williams, Elizabeth D., Pearson, John V., Kondrashova, Olga, Waddell, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505141/
https://www.ncbi.nlm.nih.gov/pubmed/37717006
http://dx.doi.org/10.1038/s41467-023-41385-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505141/
https://www.ncbi.nlm.nih.gov/pubmed/37717006
http://dx.doi.org/10.1038/s41467-023-41385-5

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