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Genome-wide promoter responses to CRISPR perturbations of regulators reveal regulatory networks in Escherichia coli

Elucidating genome-scale regulatory networks requires a comprehensive collection of gene expression profiles, yet measuring gene expression responses for every transcription factor (TF)-gene pair in living prokaryotic cells remains challenging. Here, we develop pooled promoter responses to TF pertur...

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Detalles Bibliográficos
Autores principales: Han, Yichao, Li, Wanji, Filko, Alden, Li, Jingyao, Zhang, Fuzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505187/
https://www.ncbi.nlm.nih.gov/pubmed/37717013
http://dx.doi.org/10.1038/s41467-023-41572-4