Discovery of neddylation E2s inhibitors with therapeutic activity

Neddylation is the writing of monomers or polymers of neural precursor cells expressed developmentally down-regulated 8 (NEDD8) to substrate. For neddylation to occur, three enzymes are required: activators (E1), conjugators (E2), and ligators (E3). However, the central role is played by the ubiquit...

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Detalles Bibliográficos
Autores principales: Mamun, MAA, Liu, Ying, Geng, Yin-Ping, Zheng, Yi-Chao, Gao, Ya, Sun, Jian-Gang, Zhao, Long-Fei, Zhao, Li-Juan, Liu, Hong-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505188/
https://www.ncbi.nlm.nih.gov/pubmed/37717015
http://dx.doi.org/10.1038/s41389-023-00490-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505188/
https://www.ncbi.nlm.nih.gov/pubmed/37717015
http://dx.doi.org/10.1038/s41389-023-00490-2

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