ATP7B R778L mutant hepatocytes resist copper toxicity by activating autophagy and inhibiting necroptosis

Wilson’s disease (WD) is an inherited disease characterized by copper metabolism disorder caused by mutations in the adenosine triphosphatase copper transporting β gene (ATP7B). Currently, WD cell and animal model targeting the most common R778L mutation in Asia is lacking. In addition, the mechanis...

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Detalles Bibliográficos
Autores principales: Tang, Shan, Liang, Chen, Hou, Wei, Hu, Zhongjie, Chen, Xinyue, Zhao, Jing, Zhang, Wei, Duan, Zhongping, Bai, Li, Zheng, Sujun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505209/
https://www.ncbi.nlm.nih.gov/pubmed/37717021
http://dx.doi.org/10.1038/s41420-023-01641-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505209/
https://www.ncbi.nlm.nih.gov/pubmed/37717021
http://dx.doi.org/10.1038/s41420-023-01641-5

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